Antileprosy drugs.

Synthesis and antileprosy activity of some dialkyldithiocarbamates.

OBJECTIVES To investigate the antileprosy potential of a set of original compounds with antimycobacterial activity. METHODS We developed a facile synthesis of 2-chloro-3-cyano-5-nitropyridine and synthesized a series of 3-cyano-2-dialkyldithiocarbamoyl-5-nitropyridine derivatives. In vivo therapeutic efficacy against Mycobacterium leprae was assessed in the infected mouse footpad model. RES...

The role of WHO in antileprosy drug trials.

Antithyroid Drugs

The thionamide drugs, i.e. carbimazole and its metabolite methimazole (MMI), andpropylthiouracil (PTU) have extensively been used in the management of various forms ofhyperthyroidism over the past eight decades. This review aims to summarize different aspectsof these outstanding medications. Thionamides have shown their own acceptable efficacy andeven safety profiles in ...

Antithyroid Drugs

The thionamide drugs, i.e. carbimazole and its metabolite methimazole (MMI), andpropylthiouracil (PTU) have extensively been used in the management of various forms ofhyperthyroidism over the past eight decades. This review aims to summarize different aspectsof these outstanding medications. Thionamides have shown their own acceptable efficacy andeven safety profiles in ...

Limited in vitro multiplication of Mycobacterium leprae: application to screening potential antileprosy compounds.

Inability to cultivate Mycobacterium leprae in vitro has been regarded as the bottleneck which obstructs research on modes of transmission, pathogenesis, immunization and the treatment of leprosy . The bottleneck in the cultivation problem always has been that of gaining significant information from an organism that has given no useful response to intensive inquiries by the disciplines of bioch...